- Hypertrichosis (long, curly hair )
- Delayed haircoat shedding
- Change in body conformation (muscle wasting and rounded abdomen or “potbelly”)
- Decreased athletic performance
- Change in attitude/lethargy
- Fat deposits, especially along the crest of the neck and over the tail head
- Increased drinking and urination
- Recurrent infections
- Abnormal sweating
- Absent reproductive cycle/infertility
- Neurologic deficit/blindness
There are several ways to test for Cushing's: 1) the dexamethasone suppression test and 2) the measurement of resting plasma ACTH concentration. However, one thing to note is that the time of year the tests are done can affect the results. In the fall, horses naturally increase the production of a variety of hormones as the body prepares for winter. Fortunately for Speedy, January is a great time to check ACTH concentrations.
Here's where most owners cringe and ask, "What's that going to cost?" I almost find it funny that Speedy needs a daily medication as I had just this month decided to take my boys off ALL supplements. Joke's on me I guess. The only FDA approved medication for Cushing's Disease is pergolide, brand name Prascend.
There is good news though. As of December 1, 2018, US Equestrian will now allow pergolide if the horse has been granted a Therapeutic Use Exemption (TUE). An explanation of the rule change can be read here.
I've already applied for a TUE, and my vet has submitted all necessary paperwork. When I phoned US Equestrian, the woman I spoke to had no idea how long it takes to be granted a TUE. She said that a panel must review my request. Way to go, US Equestrian. No timeline or answers make me feel great.
So that's it. Speedy now has Cushing's Disease which means daily medication, annual bloodwork, and of course getting that pesky TUE. Dr. Tolley wasn't too concerned and neither am I. There's just no cure for getting old.